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Low Opioid Prescription Might Lower Chances Of Opioid Epidemic In Future

Now, the medical professionals in the US have almost dramatically reduced the rate of prescribing opioid drugs even though it is the region where medical and recreational marijuana is legal. The researchers reported that the accessibility to recreational cannabis in the US was in a way connected with an 11.8% dip in the everyday sales of opioid prescriptions and 4.2% for medical marijuana. The legalization of medical and recreational marijuana has made the accessibility to the opioid drugs all the more easy for the people despite the stringent recreational weed laws being made effective. Such specialized drugs are basically used for extreme pain and other conditions.

The stringent laws seem to have lowered the number of getting them and also the regular availability of the opioid drug. In order to lower the chronic pain faced by many in cases of cancer, Crohn’s disease, and others, opioid drugs can be used. And the most disturbing discovery was that the family physicians prescribed more opioids when compared with any other healthcare specialties. The 2011–2018 reports showed 1.5 Billion using opioid drugs and 90% of them are being used on a regular basis. The recent opioid overdose epidemic in the US has alerted the US Centers for Disease Control and Prevention as almost 130 Americans lost their lives. The cannabis access laws could help lower the sale of prescribed opioids and in turn, hinder any future epidemic. The various laws and trade norms are being enacted to limit access to opioids. The people using opioid drugs if told to discontinue the drug could switch to dangerous drugs like heroin.

Similarly, to tackle the opioid epidemic in the US, a specific group of researchers has found a new form of cannabis to help lower the psychotic effect and it is cannabidiol (CBD), which is a non-psychoactive chemical in marijuana. The heroin users could ease their anxiety and cravings using CBD. The level of stress, increased heart rate, and escalating levels of stress hormone cortisol could all be lowered. In short, this new product could help curb the opioid crisis that has spread across the entire US.

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Novartis Drug Tasigna Is Being Repurposed For Parkinson’s Disease

A team from Georgetown University has been trying to retest Novartis’ cancer drug Tasigna that was developed to treat Parkinson’s disease in 2013. However, the toxic alpha-synuclein protein clump formation in the brains of mice proved the drug ineffective. In 2017, the drug was moved into a small phase 2 trial to basically understand Tasigna’s function in the brain in terms of relieving from Parkinson’s symptoms. The tyrosine kinase inhibitor will have new insights being added to the drug to help understand its actions in the brain. The drug is found to increase the level of dopamine in the brain. The increase in the brain chemical and decrease in neurotoxic proteins is found to very well explain the motor and non-motor functioning taking place in the brain.

The researchers basically focused on the safety of Tasigna and found the drug to lower 20% of alpha-synuclein and 30% of tau in the Parkinson’s patients. The dopamine metabolites were also found to be 50% more which means that the neurotoxic proteins are cleared and the brain is ready to use dopamine. The drug was found to stabilize the disease and improve the quality of life. The FDA had approved the drug to treat chronic myeloid leukemia with a specification of 400 mg per day. The lower doses of the drug were found to be effective when administered to Parkinson’s patients.

Likewise, Aspen Neuroscience has recently got a $6.5 Million seed round to modernize its technology to help substitute destroyed brain cells in Parkinson’s subjects. The San Diego biotech usually transplants pluripotent stem cells in Parkinson’s patients to help repair their bodies. The trials for sporadic Parkinson’s are going on whereas a gene-edited therapy for familial Parkinson’s is also being developed. The funding was provided by Axon Ventures and Domain Associates with the help of Arch Venture Partners, Alexandria Venture Investments, OrbiMed, and Section 32.

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Fish Oil Tablets Help In Improving “Dark Adaptation Capabilities”

According to a new study, fish oil supplements can considerably enhance “night vision.” Scientists from Loughborough University studied whether DHA (docosahexaenoic acid)—which is a polyunsaturated fatty acid present in fish oils—improved “dark adaptation capabilities.” This is a process the eyes experience while adjusting to new levels of light. DHA—which is mainly found in herring, mackerel, tuna, and halibut—is present in the retina in high concentrations but is not synthesized in the body. During the study, a group of 19 volunteers took four omega-3 tablets daily for 4 Weeks.

Lead authors Dr. Jim Reynolds and Dr. Paul Kelly, from the School of Science, stated that by analyzing blood levels before, throughout and after study, the team reported of direct interrelation between fatty acid levels in the body and alterations in visual capability. Dr. Kelly stated, “This is the first time that dark adaptation has been associated with fish oil’s fatty acids through direct measurement of amounts into the blood. The rising and falling levels of the acids showed the rise and fall in visual acuity. You can imagine this finding beneficial for anyone who needs their night vision to be best as possible—people in the military, police, or forensic scientists searching for fluorescent clues in the dark, for instance.”

On a similar note, recently a study showed that fish oil supplements can treat depression. Fish oil supplements might alleviate depression in some people. A few studies in adults indicate that omega-3 fatty acids might aid in treating mild-to-moderate depression, but additional research is required. Reportedly, fish oil is an ideal source of omega-3 fatty acids—that has a major role in brain function. People suffering from depression might have lower blood levels of brain chemicals known as eicosapentaenoic acid and docosahexaenoic acid, which are found in fish oil.

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Aspirin’s Efficacy In Brain Bleeding Has Urged For New Recommendations

Medical professionals have been prescribing aspirin regimens to help people deal with their heart diseases or stroke and lead their life healthily. However, the drug may be safe when it comes to the disease but its side effect, in the long run, is definitely unthought-of. The people without any heart disease consuming the medication can actually outweigh the drugs’ benefits. Aspirin dose is prescribed to people to combat heart risks such as stroke & heart attacks and also to reduce the chances of bleeding in the brain at that time. The trials to check the efficacy and safety of the disease have also been carried out.

The study showed the people consuming low doses of aspirin to have 0.63% risk of bleeding in the brain and it was also found to be more when compared to the people not having aspirin. The people having Asian backgrounds and more toward the obese side plus less than 25 Years were found to be at greater risks. The daily low dose aspirin regimen is given to the old people as the drug has the ability to prevent clot formation in the arteries. However, the American Heart Association and American College of Cardiology have a complete new guideline prepared. The guideline makes it clear that aspirin should not be prescribed to prevent heart disease for healthy, older groups who have no signs of heart disease or dealing with one.

Parallelly, a new study has shown that black Americans will not be lowered of the risks of heart disease or stroke with the practice of daily use of low-dose aspirin. The drug was found to be effective in the whites but not that efficient in the blacks as the genetic response on the drug was found to be different in both races. The researchers are working on gathering more evidence to prove the efficiency of aspirin based on race.